Meteorologists expect Isaac to travel through the eastern and central Caribbean in the coming days and experience a gradual weakening until it degrades to a tropical wave at any time.
As a result, two foreign governments and one local government have taken the decision to end their islands' storm warnings or storm watches.
"Isaac has become less organized and is now a weak Tropical Storm".
A small-craft warning means in this case that surface winds greater than or equal to 25 knots and seas equal to or greater than 3 metres (10ft) are already affecting or expected to affect the marine area.
He also urged councillors to keep a close watch on flood-prone areas in their divisions.
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According to the NHC, maximum sustained winds remain near 60 miles per hour (95 km/h) with higher gusts and gradual weakening is forecast during the next few days.
Isaac is the only system that bears monitoring over the next few days from the East Coast of the US's standpoint. The winds of Isaac are not expected to affect the Virgin Islands.
It is predicted the Carolinas could begin feeling tropical storm force winds late Wednesday or early Thursday.
The National Hurricane Center issues new updates at 8 AM, 11 AM, 2 PM, 5 PM, 8 PM, 11 PM, 2 AM, and 5 AM.
American Airlines is waiving rebooking fees for 14 Caribbean islands including Antigua, Puerto Rico and St. Lucia for flights scheduled September 12 to 14. Expect winds to increase on Saturday to 15-30mph across the entire CSRA, with the 30mph more likely in the northern/eastern areas.
At 500 PM EDT (2100 UTC), the center of Hurricane Florence was located near latitude 30.9 North, longitude 72.5 West. Florence is moving toward the northwest near 16 miles per hour (26 km/h), and this general motion, accompanied by a gradual decrease in forward speed, is expected to continue through Saturday.