United Kingdom's University of Oxford and University of Cambridge topped the global list, but the United States remains the best-represented nation in the table with 172 institutions. New Canadian additions to the top 200 include the University of Ottawa (176), Western University (190) and the University of Calgary (199).
Stanford maintained its position as the highest ranked USA institution in 3rd place, alongside Massachusetts Institute of Technology (MIT) at 4th, and California Institute of Technology at 5th.
More schools from the US joined the rankings this year, up from 157 last year to 172 institutions on the list of 1,250 schools.
After years of decline and stagnation, Japan's universities have made "some solid progress" this year, according to an influential ranking of the world's top universities released Wednesday.
Japans robot rovers lands on asteroids surface, captures incredible photos
The Minor Planet Center in 2015 christened it Ryugu, referring to Ryügü, the magical underwater palace from a Japanese folktale. The asteroids new inhabitants weigh just over 1 kilogram, stand seven centimetres (cm) in height and have a diameter of 18cm.
Seven Chinese universities feature in the top 200 this year, with several moving up in the rankings.
Tsinghua University in Beijing has overtaken the National University of Singapore as the top institution in the continent, after rising eight places to 22nd, representing the greatest rise in the top 30.
Based on THE's criteria, Johns Hopkins ranks No. 12 in the world in research, No. 19 in teaching, No. 23 in citations, No. 38 in industry income, and No. 233 in worldwide outlook.
But in an impressive debut entry, the nine-year-old Indian Institute of Technology, Indore (IIT-Indore) became India's second highest-ranked university - and a global top 400 institution - with its scores buoyed by research volume and research impact. The University of North Carolina at Chapel Hill retained its position from past year at 56th. This year also saw the UM as the top university among 11 Malaysian universities that were also being ranked by THE.