Guice sprained his left knee at LSU last season, but missed only one game.
Brady dressed but didn't play in Thursday night's 26-17 win over the Washington Redskins, and there's no guarantee he would have taken the field even if he was fully healthy, considering he sat out three of the previous four preseason openers.
The Redskins selected the 21-year old running back with the 59th overall pick in the 2018 Draft and he was due to play a major role in Washington's backfield this season.
"Grabbing him in the second round was obviously a great treat for us, but character was never a concern", coach Jay Gruden said recently, pointing to injuries and the quality of running backs as reasons for Guice falling in the draft. His season is officially over before it really got started.
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In camp, Guice had been splitting first-team carries with Kelley and Samaje Perine.
Instead, Guice's National Football League career starts with a medical redshirt. But can he run with the power and explosiveness that Guice was expected to bring?
We know Chris Thompson figures to be a big part of the backfield workforce, but he's also coming off a season-ending injury past year with a fractured right fibula Other candidates include Byron Marshall or Kapri Bibbs, who have some big-play ability. According to NFL.com, Kapri Bibbs, Byron Marshall and undrafted rookie Martez Carter are also listed on the backfield depth chart.