Asked how much motivation his players have, Guardiola said: "It is not a question that needs an answer".
The Gunners were threatening to come back into the match with City leading by Raheem Sterling's early goal, but Bernardo's top-corner effort was as perfectly timed off his laces as it was on the clock.
Benjamin Mendy makes his first Premier League start since 23 September 2017.
The Frenchman was involved in one of his side's more awkward moments midway through the first half, though. One criticism levelled at Wenger was that he was too passive when things were going against Arsenal, rarely making changes before the 70th minute, so it was novel to see Aaron Ramsey replaced by Alexandre Lacazette after just 54 minutes against City.
Cech made several saves to keep Arsenal in the game but also seemed to struggle a bit when playing with his feet, almost scoring an own goal in the first half when he mishit a back pass from Guendouzi.
PM-in-waiting Khan cleared on ballot secrecy
He also expressed concern over alleged human rights violations in the Valley, Pakistani media reported. PTI on Monday had formally announced Khan as the new Pakistan Prime Ministerial candidate.
Installed as heavy favourites to finish top again - which would make them the first team to defend the title since Manchester United in 2008-09 - City's ruthless performance was ominous for their rivals. Danilo is expected to miss the opening games of the season with an ankle injury.
"We arrived after a hard season and I told him I want to help him and would like him to be happy". And we count on him.
And it was Guendouzi who received the blame from his Arsenal teammates after Sterling bagged the first goal.
What was so remarkable about this performance from Pep Guardiola's side was that it lacked numerous key players that starred as they strolled to the title last campaign. I can't back City at odds-on, so I'll go for Draw / Man City in the Half Time / Full Time market at [5.8]. "We want to give him confidence", stated Emery during his pre-match press conference.
However, Emery is adamant that the aggressive style of play he will bring to the club will be the deciding factor this season. We spoke at half-time about taking more responsibility for the second half, to do a little more.