John McCain, US Senator And Former Republican Presidential Nominee, Dead At 81

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Former US President Barack Obama also paid his tribute to the 81-year-old Republican Senator.

Trump has criticized McCain at rallies, and continued to target him even as the Arizona senator went through treatments for brain cancer.

As news broke that Senator John McCain lost his battle to brain cancer, tributes from Delmarva's politicians immediately began pouring in. His wife Cindy and other family members were with him. "John McCain, a true friend of the Philippines and one of our champions in the United States Congress", Foreign Affairs Secretary Alan Peter Cayetano said in a statement.

His family said he would lie in state in Phoenix, Arizona, and in Washington DC before a funeral at the Washington National Cathedral and his burial in Annapolis, Maryland.

Former President Bill Clinton and former Democratic Senator Hillary Clinton, who served with McCain in the U.S. Senate, said in a statement that he "frequently put partisanship aside to do what he thought was best for the country and was never afraid to break the mold if it was the right thing to do".

Trump offered Senator McCain's family his blessing on Twitter writing: "My deepest sympathies and respect go out to the family of Senator John McCain".

With a strong presence in the Senate, McCain's next goal was the Oval Office.

Two former presidents are expected to speak at Sen.

McCain was a Vietnam War veteran who survived five years as a prisoner of war.

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The six-term senator for Arizona and 2008 Republican presidential nominee was diagnosed after doctors discovered his tumour during surgery to remove a blood clot from above his left eye last July. Even when Americans grew exhausted of war, McCain warned that more troops were needed, demanding a surge in forces that Bush later adopted.

Mr Trump and Mr McCain were at odds until the end.

Arizona will accord McCain that honor on Wednesday, when he would have turned 82.

Cayetano said McCain even shared his family's history and affinity with the Philippines and revealed that his grandfather served in the Philippines during the American Occupation and the Second World War.

The eternal comeback kid, in March 2008, John McCain clinched enough delegates to embark on the race for the White House.

Former vice-president, long-time friend and political opponent Joe Biden said Mr McCain's "impact on America hasn't ended".

"I am deeply saddened by the passing of John McCain, a great American patriot and a great supporter of Israel", Netanyahu stated.

"With his passing, we are losing a person whose personal conviction and sincerity also guided his political actions", she said in a statement.

"The party of Donald Trump began nearly 10 years ago to the day, when John McCain tapped Sarah Palin to join his ticket", Vox's politics editor, Laura McGann, wrote. It's fantastic that so many people will be given the chance to honor the American hero!