The first Manchester derby, which will pit last season's top two against each other, is due to take place on November 10 when Jose Mourinho's United make the short jounrey across town.
Manchester United will be determined to catch their neighbours - who romped home to the title last term with a 100-point tally - and Jose Mourinho and co will begin that pursuit at home to Leicester.
Nuno Espirito Santo's men won the Championship title at a canter this past season, dominating for most of the campaign and nearly notching up a century of points along the way.
They will play promoted Fulham at Wembley in their first home game of the season on the weekend of 18-19 August.
The two London sides took each other on a total of four times this season, with three out of the four being draws, and Arsenal edging the fourth.
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But the former Paris Saint-Germain and Sevilla coach has been given a daunting task at the outset of his reign, with Arsenal kicking off the 2018-19 season at home to Pep Guardiola's champions on the weekend beginning August 11 before then travelling to Stamford Bridge to face Chelsea a week later.
But when are the 10 biggest fixtures of the season taking place?
Antonio Conte's Blues travel to Huddersfield on the opening day and after the trip to Arsenal come Newcastle, Bournemouth, Cardiff, West Ham, Liverpool and Southampton.
Spurs had been due to host Watford on 1 September, but the Hornets agreed to swap the fixture's venue to Vicarage Road.