The league landed seven bids out of its nine teams, and five of those squads are set to host regionals.
The Kentucky Softball team was announced as a host team for the 2018 NCAA Softball Championship on Sunday night during the NCAA Softball Selection Show.
No. 6 seed Florida State (47-10) and Jacksonville State (33-23) are also in the region and open play in the double-elimination round at 1:30 p.m. Friday (ESPN3).
Alabama will contend with Oregon State, Wisconsin and Middle Tennessee State.
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This marks the eighth time in school history the Gamecocks have hosted a regional and the first time since 2002 the Gamecocks have been the top-seeded team.
The Pac-12 has produced 24 of the 36 NCAA softball champions but none since Arizona State won the title in 2011.
Should LSU advance, they will face the victor of the Tallahassee regional in the super regional and will travel to Tallahassee if 6 seed Florida State wins the regional.
OR is the top overall seed in the tournament. Those best-of-three tourneys will each send a team to the Women's College World Series in Oklahoma City, Oklahoma.