Syrian news agency SANA stated that "Syrian air defense shot down missiles which violated airspace over Homs".
The Pentagon said there were no reports of USA military activity, after reports from Syrian television that Syrian air defences responded to a missile attack over Homs which targeted Shayrat air base late Monday night.
The Pentagon has denied initiating strikes or conducting any other military activity in Homs province. The television report did not, however, specify who may have fired the missiles.
A Hezbollah milita media unit shortly afterward stated that Syrian air defenses intercepted three missiles that targeted the Dumayr airport in northeast Damascus.
Defense Secretary Mattis said at the time that no follow-up attacks were planned and that the Pentagon was careful to ensure the safety of Russian troops and Syrian civilians in the area.
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A military source added the Syrian military believes Israeli warplanes were responsible.
While it remains unclear who launched the attack, the reported strike comes just days after Washington, London and Paris carried out a coordinated strike in Syria in the early hours of Saturday morning.
He said: "Video shows Missile launched against unknown Target in Far East Damascus countryside".
Before the USA -led attack, Israeli warplanes had fired missiles on the T-4 airbase in the eastern countryside of Homs on April 9, killing 14 soldiers, including Iranian fighters.