The Syrian Central Media run by the government said the missiles targeted Shayrat air base in Homs. Shayrat airbase was targeted past year in a U.S. cruise missile attack in response to a chemical attack that killed at least 70 people, including children on the rebel held town of Khan Sheikhoun.
The Syrian air defenses intercepted all the missiles, said the reports, adding that the source of the missile strike was not yet known.
Big explosions were heard near Al Shayrat Air base, southeast of the city of Homs, and in eastern Qalamoun near Damascus where two other air bases are located, the Syrian Observatory for Human rights reported.
Even the USA, along side the United Kingdom along with France, ran air-strikes on Saturday in Syria to punish the Assad regimen for an apparent chemical weapons attack from civilians.
In addition to praising the recent victory of the government troops in the East Ghouta region, east of Damascus, the protesters demanded the departure of the invading U.S. troops from Syrian territory and the closure of their military bases.
Backed hackers targeting critical infrastructure, US, UK cybersecurity officials say
The joint report didn't identity any companies that have been affected, or the number of devices that have already been hacked. An email message seeking comment from the Russian embassy in Washington, D.C., received no response.
In Washington, Pentagon spokeswoman Heather Babb said: "There are no USA or coalition operations in that area".
The reported strike comes days after the US, UK and France bombed Syrian military facilities over a suspected gas attack in Douma.
Before the US -led attack, Israeli warplanes had fired missiles on the T-4 airbase in the eastern countryside of Homs on April 9, killing 14 soldiers, including Iranian fighters.
Israel has struck Syrian military targets before and was blamed for strikes earlier this month on the T4 air base in Homs.