The Athletics also hit consecutive home runs against the Angels in the season opener on March 29.
"There has to be point where he becomes a pitcher, not to say sometime during the season he won't be available to do a little bit more the day before he pitches or a day after", Scioscia said.
The Angels had 14 hits, including three each from Upton and Andrelton Simmons, and two each from Albert Pujols and Luis Valbuena.
In Houston, Jose Pirela had three hits, including a tiebreaking, two-run double as San Diego stopped the Astros' five-game winning streak. He took a 2-0 pitch from Daniel Gossett deep to center field to put the Angels on the board as they were trailing 6-0 prior to his dinger.
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Matt Joyce and Marcus Semien hit back-to-back homers as part of a five-run second inning, and the Athletics sent Parker Bridwell to the dugout after 1 2/3 innings.
Ohtani, who throws right-handed when he pitches, is scheduled to make his second Major League Baseball start on the mound Sunday against the A's.
He is now seven-for-16 with three home runs and six RBIs in his first four starts at designated hitter. Martin Maldonado drove in one run.
The A's fifth homer of the night by Olson in the top of the seventh made it 9-7, before the Angels responded with their decisive rally in the bottom of the inning.