Mourinho had been similarly dismissive when asked about Rashford, countering a statistic about the latter's lack of starts by saying he has more appearances than anyone since his Old Trafford appointment.
You can not have just 11 players.
He stressed that he can only give eleven players a starting spot amongst a squad of 22.
"If I were you, I would ask why [Romelu] Lukaku plays every match, why [Nemanja] Matic plays every match".
"You always go to that one".
"So in every club, at every level, from the top of the world to the amateur football clubs, you need more than 11 players and only 11 can start, is as simple as that, there's nothing I can do".
United could add to West Brom's relegation misery when the strugglers visit Old Trafford in Sunday's Premier League clash.
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'Only 11 can start.
"If I was you I would go in another direction", Mourinho said of Rashford.
But despite United's remarkable come-from-behind win over champions-elect Manchester City last weekend, Mourinho insists his side will not be complacent against a team he is surprised to rooted to the foot of the table, ten points from safety with five matches remaining.
Martial has started just four games since Alexis Sanchez's arrival in January.
"I wasn't aware of it before I saw it and it's something to be proud of", he said.
"It is a big challenge [for us] because in football they know anything is possible until mathematically it is impossible". I didn't, because I was not complacent, because I was working really hard, because I tried to build motivational training sessions with new exercises, with things that could motivate them, with little tactical things that I know for the players is motivation.
'And make the players understand that it's not enough to deserve to finish second, you need the elements.