Anthony Martial is also back in contention and Zlatan Ibrahimovic has returned to training, but Ander Herrera, Phil Jones, Daley Blind and Marcos Rojo are expected to miss out.
And the Portuguese admitted United have no advantage as a score draw would see Sevilla progress.
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Paul Pogba is a doubt for for the tie after the 24-year-old missed Saturday's Premier League win against Liverpool through injury and manager Jose Mourinho is unsure whether the midfielder will be available on Tuesday. "So, of course, knockout becomes more important than league matches". Earlier this week Michael Carrick confirmed his retirement from football at the end of the season, and United will be looking to give the midfield veteran a fitting send-off by potentially winning the competition for the second time in Carrick's career. "I think tomorrow is a very hard match". "I don't know. We don't know yet, but he trained a little bit after you left".
Sevilla last reached the quarter-finals of Europe's top competition in 1958, only the third edition of the European Cup, losing to eventual winners Real Madrid.
On pundit duty during the Liverpool match, former Crystal Palace manager Frank De Boer criticised Mourinho's handling of Rashford, something the United boss could not accept.
On Rashford he added: "He started, he had a good match and I'm not just speaking about scoring goals because, for me, the analysis of a performance is much more than analysing the number of goals or assists".