Tsvangirai had been in and out of hospital since disclosing in June 2016 that he had colon cancer.
Tsvangirai by no means had an easy political career, as his main aim was to beat former Zimbabwe and Zanu PF president Robert Mugabe, to end his tyrannical reign over the region.
Earlier this month, it was reported the political rival of former Prime Minister Robert Mugabe was "critically ill" in hos pital in South Africa.
"We have lost a doyen of democracy, an icon. a crucial soldier", Chamisa told hundreds of party supporters, speaking from a balcony on the party headquarters in downtown Harare.
Sure Kamhunga- The only opposition party leader who was courageous despite mortal danger and brutality and beatings and jail to take Robert Mugabe regime head on.
The MDC emerged as the country's economy first began to spiral and Mugabe held on tighter.
Brezh Malaba- Morgan Tsvangirai defeated one of the most evil dictatorship on the face of the planet but they denied him power.
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Mugabe was forced to resign previous year following a military coup led by his Zanu-PF party. He accused Mugabe of rigging the election and challenged him in the courts.
Sarkaal katirsan Xisibigiisa MDC ayaa xaqiijiyay in Tsvangirai uu u geeriyooday xanuunka Kansarka dhanka caloosha uga dhacay, oo mudo la xanuunsanayay. He was a courageous democrat, a genuine leader, the president we never had.
Some supporters drove around the city centre playing party music honouring Tsvangirai.
The politician suffering from cancer died in South Africa on Wednesday.
Tsvangirai addresses an MDC rally in Mutare in 2000.
"I have learned with deep sorrow the death of Tsvangirai".
Tsvangirai was born on 10 March 1952 in the Gutu area of Southern Rhodesia, one of nine children of a carpenter.