"If the same policy of confusion and uncertainties about the JCPOA contiues, if companies and banks are not working with Iran, we can not remain in a deal that has no benefit for us", said Abbas Araqchi, Iran's deputy foreign minister.
In Iran's eyes, it is Israel that is the destabilizing force in the Middle East. "Fear of war is everywhere in our region unfortunately because of the interference by foreign powers and wrong policies and miscalculations of some players inside the region, and of course the hegemonic policies of the Israeli regime", Araghchi said.
But Trump called it the "worst deal ever" and has demanded that European partners "fix the awful flaws" or he would re-impose sanctions, although he has so far issued "waivers" upholding the deal.
It would be a "big mistake if anybody tried to link" the existing nuclear deal with other concerns including Iran's missile program or regional policy, Araghchi said.
"I don't think the deal can survive in this way".
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Trump also objects to "sunset" clauses in the agreement that mean some limits on Iran's nuclear program will begin expiring after 10 years. He accused Trump's administration of violating JCPOA "on a daily basis nearly".
He said the White House had created a "destructive atmosphere" around the deal and that Trump's frequent comments about it were "like a poison".
While the deal largely ended nuclear-related sanctions on Tehran, other sanctions, including those targeting its support for terror groups like Hezbollah and its ballistic missile program, continue despite the deal.
Much of the criticism of the deal revolves around its so-called "sunset" clauses, which detail when the various restrictions imposed on Iran's nuclear programme expire.
He wants all three strengthened if the United States is to stay in the nuclear deal, which is known by diplomats as the Joint Comprehensive Plan of Action, or JCPOA. Araghchi warned that the world faces "another nuclear crisis" if the deal collapses.