Secretary of State Rex Tillerson, Commerce Secretary Wilbur Ross and U.S. Trade Representative Robert Lighthizer will be part of the delegation, the White House announced.
President Donald Trump plans to bring a big delegation with him to the small Swiss ski town of Davos in two weeks, including eight Cabinet members and some of the White House's senior staff.
"I don't think it's a hangout for globalists", Mnuchin said, using a term popularized by the nationalist wing of the Republican Party.
Mnuchin tells reporters that administration officials attending the gathering of numerous world's most influential leaders will be promoting Trump's "America First" agenda and ways to bring jobs and economic investment to the U.S. "We're thrilled that the President is coming".
Palestinians will not be 'blackmailed' by Trump funding threat: senior official
The Palestinian President's office rebuffed Mr Trump's remarks, saying: " Jerusalem is not for sale, neither for gold nor silver". However, it is also a disputed territory, contested by both Israel and Palestine, which sees it as a capital of its future state.
The former Goldman Sachs banker and Hollywood financier added "the economy that is good for the U.S.is good for the world". This year's forum is scheduled to run January 23-26.
Trump is a billionaire but ran a populist campaign aimed at energizing working-class Americans he said had been ignore by the Democrats.
He says he and other administration officials have no interest in "rubbing elbows" with the other attendees. "This is about meeting business leaders". It is all about creating jobs and economic growth for the US ...
Mnuchin said that Trump would talk about "reciprocal, free, and fair trade" at the summit.
"The President will talk a lot about his economic program and the impact on the global economy", he said.