Deontay Wilder punches Artur Szpilka during their WBC Heavyweight Championship bout.
Ortiz was fined $25,000 (£18,497) but not banned from the sport as the World Boxing Council said the Cuban took the drugs for high blood pressure.
Showtime will produce the event and will televise it either on Showtime or on sister network CBS.
When the original fight with 38-year-old Ortiz was postponed, Wilder then defended his WBC title against fellow American Bermane Stirmane and won with a first-round knockout.
Deontay Wilder to defend WBC title against Luis Ortiz
The American has been tipped to fight Anthony Joshua at some point in 2018 but will first take on mandatory challenger Ortiz at the Barclays Center, Brooklyn.
They were supposed to meet in November but Ortiz tested positive for a banned substance and "The Bronze Bomber" instead faced Bermane Stiverne. Ortiz, meanwhile, took a last-minute return bout on December 8 and finished an overmatched Daniel Martz with one punch. Be ready, I don't want no excuses. Luis Ortiz, you will have the fight.
The bout will mark Wider's third appearance at the Barclay's Center following his previous bout with Bermane Stiverne on November 4th a year ago, securing a brutal first round knockout against his handpicked mandatory challenger following the then provisional suspension of Ortiz.
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