Berizzo recently returned to the club's dugout after being diagnosed with prostate cancer.
They hope to name his replacement soon after the winter break.
"Sevilla FC's board of directors, who met on the afternoon of Friday the 22nd of December, has taken the decision to dismiss first-team coach, Eduardo Berizzo, on account of the team's poor run of results", read a statement on Sevilla's official website.
"Sevilla FC wishes to thank Eduardo Berizzo for his professionalism and commitment shown as well as the treatment given to the members of the club since his arrival".
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Berizzo's condition was made public after Seville came from three goals down to draw 3-3 with Liverpool in the Champions League group stage on 21 November.
The former Argentine global then missed four matches as he underwent surgery on a tumour with his assistant coach Ernesto Marcucci taking charge.
The 48-year-old had enjoyed plenty of success at former club Celta Vigo, whom he helped reach two Copa del Rey semifinals and an Europa League semifinal in his three season in Galicia.
The club's board have acted swiftly to relieve Berizzo of his duties just seven months into his reign as manager with Sevilla now fifth in La Liga table.